Hydrochloric Acid → HCID 86740742, 화합물

HRID 1380955

반응식

HRID 1380955 반응식
[C:1]1([CH2:7][CH:8](Br)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][O:19][N:20]([CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[C:21](=[O:23])[CH3:22])=[CH:14][CH:13]=1.N1CCCC[CH2:31]1.[ClH:36]>C1(C)C=CC=CC=1>[Cl-:36].[C:1]1([CH:7]([CH3:8])[CH2:31][NH+:27]2[CH2:28][CH2:29][CH:24]([N:20]([O:19][CH2:18][C:15]3[CH:14]=[CH:13][C:12]([F:11])=[CH:17][CH:16]=3)[C:21](=[O:23])[CH3:22])[CH2:25][CH2:26]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8082PiperidineHCID 102754(2-Bromopropyl)benzeneHCID 23324804HCID 23324804, 화합물

생성물 1

HCID 86740742HCID 86740742, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Combining 1-phenyl-2-bromopropane with 4-[N-(4-fluorophenyl)methoxyacetamido]piperidine in the procedure similar to that of Example XII the base 1-(2-phenyl-1-propyl)-4-[N-4-fluorophenyl)methoxyacetamido]piperidine is formed. Dry HCl is added to a toluene solution of the base to obtain 1-(2-phenyl-1-propyl)-4-[N-(4-fluorophenyl)methoxyacetamido]piperidinium chloride, m.p. 250° C.

후처리

  1. customis formed

출처 및 근거

ORD 기록
ord-9d3b91c994cd4dee8a24936b76f97787
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04584303

연결된 노트

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