Potassium Fluoride → 2,4-Dinitro-5-fluorophenoxyacetonitrile

HRID 1381634노트

반응식

HRID 1381634 반응식
[N+:1]([C:4]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11](Cl)=[CH:10][C:5]=1[O:6][CH2:7][C:8]#[N:9])([O-:3])=[O:2].[F-:18].[K+]>CS(C)=O>[N+:1]([C:4]1[CH:13]=[C:12]([N+:14]([O-:16])=[O:15])[C:11]([F:18])=[CH:10][C:5]=1[O:6][CH2:7][C:8]#[N:9])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 522689Potassium FluorideHCID 14250577(5-Chloro-2,4-dinitrophenoxy)acetonitrile

생성물 1

HCID 140535322,4-Dinitro-5-fluorophenoxyacetonitrile수율 89.3%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

A suspension of 2,4-dinitro-5-chlorophenoxyacetonitrile (5.0 g) and potassium fluoride (1.7 g) in dimethylsulfoxide (25 g) was stirred at 83° to 85° C. for 1 hour. The reaction mixture was poured into ice-water (300 ml) and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The precipitated crystals were collected by filtration and washed with ether to give crystalline 2,4-dinitro-5-fluorophenoxyacetonitrile (4.18 g; yield, 89.3%). M.P., 118°-118.5° C. (recrystallized from methanol).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. filtrationThe precipitated crystals were collected by filtration
  6. washwashed with ether

출처 및 근거

ORD 기록
ord-9e9df53f52724bdda0be8e41cc5f438a
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803270

반응 노트

불러오는 중…