2-(5-Fluoro-2,4-dinitrophenoxy)acetic acid → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

HRID 1381640노트

반응식

HRID 1381640 반응식
[N+:1]([C:4]1[CH:14]=[C:13]([N+:15]([O-])=O)[C:12]([F:18])=[CH:11][C:5]=1[O:6][CH2:7][C:8](O)=[O:9])([O-])=O.[H][H]>C(O)C.[Pt](=O)=O>[F:18][C:12]1[C:13]([NH2:15])=[CH:14][C:4]2[NH:1][C:8](=[O:9])[CH2:7][O:6][C:5]=2[CH:11]=1

참가 물질

5

반응물 2

HCID 3028912-(5-Fluoro-2,4-dinitrophenoxy)acetic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 103133897-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one수율 91.4%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A suspension of 2,4-dinitro-5-fluorophenoxyacetic acid (0.25 g) and platinum dioxide (80 mg) in ethanol (10 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 130 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.16 g; yield, 91.4%). M.P., more than 300° C.

후처리

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-05e29bf0c8854d54a844653f553cc357
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04803270

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