Acetic Anhydride → 6-Amino-1-propyluracil

HRID 1381852

반응식

HRID 1381852 반응식
[C:1](CC(O)=O)#[N:2].[CH2:7]([NH:10][C:11]([NH2:13])=[O:12])[CH2:8][CH3:9].C(O[C:18](=[O:20])[CH3:19])(=O)C>>[NH2:2][C:1]1[N:10]([CH2:7][CH2:8][CH3:9])[C:11](=[O:12])[NH:13][C:18](=[O:20])[CH:19]=1

참가 물질

4

반응물 3

HCID 7918Acetic AnhydrideHCID 9740Cyanoacetic acidHCID 12303Propylurea

생성물 1

HCID 1045626-Amino-1-propyluracil

실험 절차

To a solution of 47 g (0.55 mol) cyanoacetic acid and 100 ml of acetic anhydride was added 50 g (0.49 mol) of n-propylurea. The solution was stirred at 60°-70° C. for 1 hour. After cooling; white crystals were filtered off and washed with ethanol. Yield 56.2 g (68%) (I). This was stirred in 100 ml of hot water and 60 ml of 2N NaOH was added in portions so the solution the whole time was basic. The reaction mixture was refluxed for 20 minutes and then neutralized with 5N HCl. After cooling, white crystals were filtered off. Yield 34.3 g (61%) (II) NMR.

후처리

  1. temperatureAfter cooling
  2. filtrationwhite crystals were filtered off
  3. washwashed with ethanol
  4. stirringThis was stirred in 100 ml of hot water
  5. addition60 ml of 2N NaOH was added in portions so the solution the whole time
  6. temperatureThe reaction mixture was refluxed for 20 minutes
  7. temperatureAfter cooling
  8. filtrationwhite crystals were filtered off

출처 및 근거

ORD 기록
ord-c68cad846c234caebdb70c588c68a857
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04804664

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