Triethylamine → 2-Methoxy-8-methylcarbamoyl-2,8-diazaspiro[4,5]decane-1,3-dione

HRID 1381942노트

반응식

HRID 1381942 반응식
Cl.[CH3:2][O:3][N:4]1[C:8](=[O:9])[CH2:7][C:6]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:5]1=[O:15].C(N(CC)CC)C.[CH3:23][N:24]=[C:25]=[O:26]>O>[CH3:2][O:3][N:4]1[C:8](=[O:9])[CH2:7][C:6]2([CH2:14][CH2:13][N:12]([C:25](=[O:26])[NH:24][CH3:23])[CH2:11][CH2:10]2)[C:5]1=[O:15]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 30882852,8-Diazaspiro(4,5)decane-1,3-dione, 2-methoxy-, monohydrochloride

생성물 1

HCID 212754282-Methoxy-8-methylcarbamoyl-2,8-diazaspiro[4,5]decane-1,3-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 2-methoxy-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride (1.5 g) in water (20 ml) was added triethylamine (1 ml), followed by methyl isocyanate (1 ml), and this was followed by stirring at room temperature for 30 minutes. The water was then evaporated off under reduced pressure. The residue was directly subjected to silica gel column chromatography (eluent; chloroform-acetone-methanol=10:3:2 (v/v)), and the solvent for the solution containing the desired product was evaporated off under reduced pressure to obtain 1.4 g of a colorless oily compound.

후처리

  1. customThe water was then evaporated off under reduced pressure
  2. additionthe solvent for the solution containing the desired product
  3. customwas evaporated off under reduced pressure

출처 및 근거

ORD 기록
ord-eafad1bcea084cac804c664897443a18
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04804665

반응 노트

불러오는 중…