Sulfamic Acid → Acesulfame

HRID 1381973

반응식

[C:1]([NH2:7])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[S:8](=O)(=[O:11])([OH:10])N>>[CH3:5][C:3]1[O:4][S:8](=[O:11])(=[O:10])[NH:7][C:1](=[O:6])[CH:2]=1

참가 물질

반응물 2

HCID 5987Sulfamic Acid2회

HCID 80077Acetoacetamide

생성물 1

HCID 36573Acesulfame

실험 절차

cyclizing the acetoacetamide derivative; the process comprises using, as the sulfamic acid derivative in stage (a), a salt of sulfamic acid which is at least partly soluble in the inert organic solvent employed, cyclizing the acetoacetamide-N-sulfonate formed in this stage or the free acetoacetamide-N-sulfonic acid in stage (b) by the action of an at least approximately equimolar amount of SO3, if appropriate in an inert inorganic or organic solvent, to give 6-methyl-3,4-dihydro-1,2,3-oxa-thiazin-4-one 2,2-dioxide, and then, if desired, also neutralizing with a base, in a stage (c), the product obtained here in the acid form.

후처리

customformed in this stage

출처 및 근거

ORD 기록: ord-a6387a52fe2d426d8c8d1b4273ed9d87
출처 데이터셋: uspto-grants-1989_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04804755

연결된 노트

불러오는 중…