Benzamide, N-cyano- → HCID 178512389, 화합물

HRID 1382446

반응식

HRID 1382446 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:4][CH2:3]1.[C:19]([NH:27][C:28]#[N:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[C:19]([NH:27][C:28]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:6][CH2:7]1)=[NH:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 84805Benzamide, N-cyano-HCID 111958234-Amino-1-(2-naphthyl)methylpiperidine

생성물 1

HCID 178512389HCID 178512389, 화합물수율 40.4%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoyl cyanamide (0.67 g, 0.0042 m) in toluene (100 cm3) were refluxed for 15 hours. The solvent was evaporated and the residue recrystallised from the minimum amount of isopropyl alcohol and recrystallised twice more from ethanol to give 0.65 g of the title compound, m.p. dihydrochloride quarter hydrate, m.p. 260°-262° C.

후처리

  1. customThe solvent was evaporated
  2. customthe residue recrystallised from the minimum amount of isopropyl alcohol
  3. customrecrystallised twice more from ethanol

출처 및 근거

ORD 기록
ord-8dae87f3430247cfba9c9f42b16f3681
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806552

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