2,2,2-Trifluoroacetophenone → 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene

HRID 1382633

반응식

HRID 1382633 반응식
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl-].C1([P+](C2C=CC=CC=2)(C2C=CC=CC=2)[CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)C=CC=CC=1.[O-]CC.[Na+]>C(O)C>[C:5]1([C:3]([C:2]([F:12])([F:11])[F:1])=[CH:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 99052,2,2-TrifluoroacetophenoneHCID 2723922Sodium ethoxideHCID 2733554(4-Fluorobenzyl)triphenylphosphonium chloride

생성물 1

HCID 570563672-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene수율 90%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,2,2-Trifluoroacetophenone is reacted with triphenyl-(4-fluorobenzyl)-phosphonium chloride (R. A. Jones: Australian J. Chem. 18, 903-6 (1965) in ethanol in the presence of sodium ethoxide. 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene is obtained with a yield of 90%; b.p.: 105°-107° C./0.2 mm Hg, m.p.: 35°-41° C.

출처 및 근거

ORD 기록
ord-018a985c58db4b17bdd4b5052bf80006
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04806685

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