1,1-Dibutoxytrimethylamine → HCID 178481358, 화합물

HRID 1382721

반응식

HRID 1382721 반응식
[C:1]([C:4]1[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=1[NH2:10])(=[O:3])[CH3:2].[CH2:15](OC(OCCCC)N(C)C)CCC>CN(C=O)C>[OH:3][C:1]1[C:4]2[C:5](=[O:14])[N:6]([CH3:13])[C:7](=[O:12])[N:8]([CH3:11])[C:9]=2[N:10]=[CH:15][CH:2]=1

참가 물질

4

반응물 2

HCID 876831,1-DibutoxytrimethylamineHCID 3200235-Acetyl-6-amino-1,3-dimethyluracil

생성물 1

HCID 178481358HCID 178481358, 화합물수율 70.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

0.8 g of 5-acetyl-6-amino-1,3-dimethyluracil was dissolved in DMF and 4 ml of dimethylformamide dibutylacetal was added thereto. The solution was heated for 8 hr at 80° C. and distilled under reduced pressure. After purification by silica gel column chromatography, the crude product was recrystallized from ethanol to give 0.59 g of 5-hydroxy1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 14).

후처리

  1. distillationdistilled under reduced pressure
  2. customAfter purification by silica gel column chromatography
  3. customthe crude product was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-303b74edd28c4f0da0843227cddd9aa1
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808587

연결된 노트

불러오는 중…