Sodium Chloride → 4,4-Dimethyl-6-(1-hydroxyethyl)chroman

HRID 1382909노트

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HRID 1382909 반응식
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH2:9][CH2:8][C:7]2([CH3:15])[CH3:14])(=[O:3])[CH3:2].[BH4-].[Na+].[Cl-].[Na+]>CO>[CH3:15][C:7]1([CH3:14])[C:6]2[C:11](=[CH:12][CH:13]=[C:4]([CH:1]([OH:3])[CH3:2])[CH:5]=2)[O:10][CH2:9][CH2:8]1

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 4311764Sodium borohydrideHCID 134781601-(4,4-Dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)ethan-1-one

생성물 1

HCID 140102484,4-Dimethyl-6-(1-hydroxyethyl)chroman수율 99%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 6.0 g of 6-acetyl-4,4-dimethylchroman in 50 ml of methanol was added, all in one portion, with stirring, 3.78 g of sodium borohydride at ca. 0° C. Stirring was continued at ca. 0° C. for 1.5 hours, and then the reaction mixture was poured into 500 ml of saturated sodium chloride solution. The resulting mixture was extracted with diethyl ether, and the combined ether extracts were dried (MgSO4) and evaporated in vacuo to give 6.0 g of the title compound as an oil.

후처리

  1. customat ca. 0° C
  2. stirringStirring
  3. extractionThe resulting mixture was extracted with diethyl ether
  4. dry with materialthe combined ether extracts were dried (MgSO4)
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-752af348fc5e4b3c8d6b1a3553a906ad
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808597

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