Hydrogen Bromide → 2-[3-(Methylamino)propyl]benzthiazole dihydrobromide

HRID 1382923노트

반응식

HRID 1382923 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13](C)[C:14](=O)OCC1C=CC=CC=1.CCOCC.[BrH:30]>C(O)(=O)C>[BrH:30].[BrH:30].[CH3:14][NH:13][CH2:12][CH2:11][CH2:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 53819401Benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate

생성물 1

HCID 212734622-[3-(Methylamino)propyl]benzthiazole dihydrobromide수율 93.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

1.7 g (4.99 mmol) of benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate are dissolved at 0° in 40% hydrogen bromide in acetic acid and stirred at room temperature for 20 hours. Thereupon, 60 ml of ether are added and, after 1.5 hours, the precipitate formed is filtered off. After washing the crystalline precipitate with ether and drying there are obtained 1.71 g (93.1%) of 2-[3-(methylamino)propyl]benzthiazole dihydrobromide, m.p. 196°-197°.

후처리

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washAfter washing the crystalline precipitate with ether
  4. customdrying there

출처 및 근거

ORD 기록
ord-42f63d39ede14e90ae2a9acd9c59d6b5
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808605

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