Methanol → HCID 21274166, 화합물

HRID 1383219

반응식

HRID 1383219 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:15]2[CH2:17][CH2:16]2)=[C:9]2SCCCS2)=[CH:4][CH:3]=1.[OH2:18].[CH3:19][OH:20]>C(OCC)C.[Hg](Cl)Cl>[CH:15]1([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[C:9]([O:20][CH3:19])=[O:18])[CH2:17][CH2:16]1

참가 물질

6

반응물 3

HCID 887MethanolHCID 962WaterHCID 539201222-[(4-Chlorophenyl)cyclopropylmethylene]-1,3-dithiane

생성물 1

HCID 21274166HCID 21274166, 화합물

시약·촉매·용매 2

HCID 24085Mercuric Chloride촉매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 10.0 grams (0.036 mole) of 2-[(4chlorophenyl)cyclopropylmethylene]-1,3-dithiane, 24.0 grams (0.086 mole) of mercury (II) chloride, and 5 mL of water in 50 mL of methanol was stirred at ambient temperature for 18 hours. The reaction mixture was heated at reflux for one hour, cooled, and then was diluted with diethyl ether. The mixture was filtered through diatomaceous earth and then was dried with magnesium sulfate. The mixture was filtered through silica gel, and the filtrate was concentrated under reduced pressure, yielding 5.9 grams of methyl 2-cyclopropyl-2-(4-chlorophenyl)acetate as an oil. The nmr spectrum was consistent with the proposed structure. The reaction was run again to produce an additional 7.1 grams of the acetate.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for one hour
  3. temperaturecooled
  4. filtrationThe mixture was filtered through diatomaceous earth
  5. dry with materialwas dried with magnesium sulfate
  6. filtrationThe mixture was filtered through silica gel
  7. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bed9866317c6414aa5b19fd0e979cfd9
출처 데이터셋
uspto-grants-1989_02
특허 번호
US04808762

연결된 노트

불러오는 중…