p-Toluenesulfonic acid → HCID 66660252, 화합물

HRID 1383842노트

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HRID 1383842 반응식
Cl[C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][C:7]=1[C:8]1[O:9][CH:10]=[CH:11][CH:12]=1.Cl.C([N:17]([CH2:20][CH3:21])CC)C.[C:22]1(C)C=[CH:26][C:25](S(O)(=O)=O)=[CH:24][CH:23]=1.[CH3:33][N:34]1[CH:38]=[N:37][C:36]([CH2:39][OH:40])=[N:35]1.[N:41]1C=CC=CC=1CO>C(N(CC)CC)C>[O:9]1[CH:10]=[CH:11][CH:12]=[C:8]1[C:7]1[C:2]([O:40][CH2:39][C:36]2[N:37]=[CH:38][N:34]([CH3:33])[N:35]=2)=[N:3][N:4]2[C:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:17][N:41]=[C:5]2[CH:6]=1

참가 물질

7

반응물 5

HCID 6101p-Toluenesulfonic acidHCID 11130Triethylamine hydrochlorideHCID 11474PiconolHCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanolHCID 21187529Pyridazine, 3,6-dichloro-4-(2-furanyl)-

생성물 1

HCID 66660252HCID 66660252, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

This compound was prepared from 3,6-dichloro-4-(furan-2-yl)-pyridazine (Example 140 part a) using the procedures described in Example 16 Steps b) and c) except 1.1 equivalents of triethylamine hydrochloride was used in Step b) instead of 1.1 equivalents of p-toluenesulphonic acid and triethylamine, and (1-methyl-1 H-1,2,4-triazol-3yl)methanol (Example 65) was used in Step c) instead of 2-pyridylcarbinol. Data for the title compound: m.p. 257-259° C. (DMF). 1H NMR (360 MHz, d6-DMSO) 3.91 (3 H s), 5.63 (2 H, s), 6.74 (1 H, dd, J=4 and 2 Hz), 7.33 (1 H, d, J=4 Hz), 7.54-7.65 (3 H, m), 7.99 (1 H, d, J=2 Hz), 8.44 (1 H, s), 8.46 (2 H, d, J=7 Hz), 8.57 (1 H, s). MS (ES+) 374 [MH]+. Anal. Found C, 60.68; H 4.11; N, 25.82. C19H15N7O2. 0.15 H2O requires C, 60.68; H, 4.10; N, 26.07%.

출처 및 근거

ORD 기록
ord-d4036760b4484aee8ec56abe6eb4d119
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255305B1

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