Hydrogen Bromide → Ethyl 2-benzyl-4-bromobutanoate

HRID 1383960

반응식

HRID 1383960 반응식
[CH2:1]([CH:8]1[CH2:13][CH2:12][O:11][C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BrH:14].[CH2:15](O)[CH3:16]>>[CH2:1]([CH:8]([CH2:13][CH2:12][Br:14])[C:9]([O:11][CH2:15][CH3:16])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 5627582-Benzyl-butyrolactone

생성물 1

HCID 21188482Ethyl 2-benzyl-4-bromobutanoate

반응 조건

온도
45 °C

실험 절차

In absolute ethanol (78 ml), α-benzyl-γ-butyrolactone (14 g, 80 mmol) was added and then saturated for thirty minutes with gaseous hydrogen bromide, maintaining the temperature below 50° C. The reaction was then heated to 45° C. and stirred at this temperature for 16 hours. The solution was concentrated under reduced pressure and the resulting oil was taken into ethyl acetate (500 ml), washed once with water, and then dried over magnesium sulfate. The solvents were removed in vacuo to yield 15.13 grams of tan oil.

후처리

  1. temperaturemaintaining the temperature below 50° C
  2. concentrationThe solution was concentrated under reduced pressure
  3. washwashed once with water
  4. dry with materialdried over magnesium sulfate
  5. customThe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-a94ccb2a582547f6bf1e5a7945b8f79f
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06255494B1

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