Phosphorus pentachloride → Benzyl 3,4,5-trimethoxyphenylphosphonochloridate

HRID 1384045노트

반응식

HRID 1384045 반응식
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[CH3:7][O:8][C:9]1[CH:10]=[C:11]([P:19](=[O:36])(OCC2C=CC=CC=2)[O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16]>C(Cl)(Cl)Cl>[CH3:7][O:8][C:9]1[CH:10]=[C:11]([P:19]([Cl:2])(=[O:36])[O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:12]=[C:13]([O:17][CH3:18])[C:14]=1[O:15][CH3:16]

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 54545930Dibenzyl 3,4,5-trimethoxyphenylphosphonate

생성물 1

HCID 21185535Benzyl 3,4,5-trimethoxyphenylphosphonochloridate

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
60 °C

실험 절차

Phosphorous pentachloride (1.15 mmol) is added to a mixture of diester 2 (1 mmol) in 5 mL of CHCl3. The mixture is heated at 60° C. until 1H NMR of an aliquot shows that no starting material remains (approximately 4 hours). The mixture is cooled to room temperature, and the volatile components are removed in vacuo overnight

후처리

  1. custom(approximately 4 hours)
  2. temperatureThe mixture is cooled to room temperature
  3. customthe volatile components are removed in vacuo overnight

출처 및 근거

ORD 기록
ord-951b36517c3041079e84d5fcd56e65b5
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06258360B1

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