Sodium Hydroxide → HCID 21183693, 화합물
반응식
C[O:2][C:3](=[O:29])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[CH:21]=[C:20]3[C:16]([C:17]([CH2:27][CH3:28])=[N:18][N:19]3[CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[CH:15][CH:14]=2)=[O:12])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH:22]1([N:19]2[C:20]3[C:16](=[CH:15][CH:14]=[C:13]([C:11]([NH:10][C:7]4[CH:6]=[CH:5][C:4]([C:3]([OH:29])=[O:2])=[CH:9][CH:8]=4)=[O:12])[CH:21]=3)[C:17]([CH2:27][CH3:28])=[N:18]2)[CH2:23][CH2:24][CH2:25][CH2:26]1참가 물질
4
실험 절차
A mixture of 380 mg (0.971 mmol, 1.0 equiv) 4-[(1-cyclopentyl-3-ethyl-1H-indazole-6-carbonyl)-amino]-benzoic acid methyl ester, 4 mL 1N NaOH and 20 mL methanol was heated to reflux for 40 minutes. After cooling to room temperature, the reaction mixture was concentrated on a rotary evaporator, and the residue diluted with 150 mL H2O, acidified to pH=1, and extracted 2×50 mL ethyl acetate. The organic extracts were combined, washed 1×25 mL each H2O, brine, and dried over Na2SO4. Filtration, concentration of filtrate, and drying at high vacuum, room temperature gave 298 mg (81%) of a white crystalline solid: mp 249-251° C.; Anal. calcd for C22H23N3O3: C, 70.00; H, 6.14; N, 11.13. Found: C, 69.66; H, 6.13; N, 11.08.