Methanol → HCID 18475331, 화합물

HRID 1386497노트

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HRID 1386497 반응식
C([C:3]([C:12]#[N:13])([CH:7]([CH:9]1[CH2:11][CH2:10]1)[CH3:8])[C:4]([OH:6])=[O:5])C.CO.[OH-].[Na+]>O1CCCC1>[C:12]([CH:3]([CH:7]([CH:9]1[CH2:10][CH2:11]1)[CH3:8])[C:4]([OH:6])=[O:5])#[N:13]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium Hydroxide2회HCID 18475322HCID 18475322, 화합물

생성물 1

HCID 18475331HCID 18475331, 화합물수율 86.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

39.8 g (0.22 mol) of ethyl 2-cyano-3-cyclopropylbutanoic acid were refluxed for 4 hours in a mixture of in each case 150 ml of methanol, tetrahydrofuran and 2 N sodium hydroxide solution. For working-up, 200 ml of 2 N sodium hydroxide solution were added and the mixture was extracted repeatedly with diethyl ether. The aqueous phase was subsequently acidified by adding hydrochloric acid and also extracted with ether. After this organic phase had been dried and concentrated, 29 g (yield 86%) of 2-cyano-3-cyclopropylbutanoic acid were obtained.

후처리

  1. extractionthe mixture was extracted repeatedly with diethyl ether
  2. additionby adding hydrochloric acid
  3. extractionalso extracted with ether
  4. customAfter this organic phase had been dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b78dc391b4364aec908a771c12cc1c70
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265447B1

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