Sodium Iodide → 8-Iodo-1-octyne

HRID 1386649

반응식

HRID 1386649 반응식
[CH2:1](OS(C1C=CC(C)=CC=1)(=O)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[CH:8].[I-:20].[Na+]>CC(C)=O>[I:20][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[CH:8]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 10779145Oct-7-yn-1-yl 4-methylbenzene-1-sulfonate

생성물 1

HCID 226215568-Iodo-1-octyne수율 94.2%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 7-octynyl-p-toluenesulfonate (18.3 g, 65.2 mmol), sodium iodide (9.77 g, 65.2 mmol) and acetone (91 ml) was allowed to react for four hours under reflux. After cooling, the precipitates were removed by filtration, and the filtrate was concentrated. The resulting residue was purified by silica gel column chromatography (eluent; hexane) to afford 14.5 g of 8-iodo-1-octyne (yield; 94.2%).

후처리

  1. customto react for four hours
  2. temperatureunder reflux
  3. temperatureAfter cooling
  4. customthe precipitates were removed by filtration
  5. concentrationthe filtrate was concentrated
  6. customThe resulting residue was purified by silica gel column chromatography (eluent; hexane)

출처 및 근거

ORD 기록
ord-31fa64294bc44b35b52744d807888dcc
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265569B1

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