1-t-Butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl) piperidine → 4-(3-(3,5-Difluorophenyl)propyl)piperidine

HRID 1386745노트

반응식

HRID 1386745 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[F:24][C:19]1[CH:18]=[C:17]([CH2:16][CH2:15][CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:22]=[C:21]([F:23])[CH:20]=1

참가 물질

4

반응물 1

HCID 211806591-t-Butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl) piperidine

생성물 1

HCID 211806144-(3-(3,5-Difluorophenyl)propyl)piperidine수율 70%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

A solution of 1-t-butoxycarbonyl-4-(3-(3,5-difluorophenyl)propyl)piperidine (from EXAMPLE 95, Step D) in 2.0 N HCl in MeOH was stirred at rt for 20 h. The solution was concentrated. Ether was added and the mixture was concentrated to remove excess HCl to afford 381 mg (70% yield from EXAMPLE 95, Step C) of the title compound: 1H NMR (500 MHz, CD3OD) δ 1.32-1.37 (4H), 1.64-1.68 (1H), 1.94 (d, J=14.2, 2H), 2.64 (t, J=7.3, 2H), 2.95 (t, J=13.1, 2H), 3 35 (d, J=12.6, 2H), 6.69-6.78 (m, 1H). 6.80 (d, J=8.2, 2H).

후처리

  1. concentrationThe solution was concentrated
  2. additionEther was added
  3. concentrationthe mixture was concentrated
  4. customto remove excess HCl

출처 및 근거

ORD 기록
ord-89c15acd128948e7b09d01d3211c065b
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265434B1

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