Potassium Carbonate → HCID 53804942, 화합물

HRID 1386829

반응식

HRID 1386829 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1.[I:17][CH2:18][CH2:19][CH2:20]I.C(=O)([O-])[O-].[K+].[K+]>>[I:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:12]=[N:13][O:14][C:15]=2[CH3:16])=[O:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 123141,3-DiiodopropaneHCID 19439747N-(4-Hydroxyphenyl)-5-methyl-1,2-oxazole-4-carboxamide

생성물 1

HCID 53804942HCID 53804942, 화합물

실험 절차

6.5 g (0.03 mol) of 5-methylisoxazole-4-carboxylic acid (4-hydroxyphenyl)amide are dissolved in 57 ml (0.5 mol) of 1,3-diiodopropane and 26.2 g (0.19 mol) of finely ground potassium carbonate are added with intensive stirring. The reaction is complete after approximately 4 h. Working up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid. The yield of the process was 6.7 g.

후처리

  1. filtrationWorking up is carried out by means of filtration, concentration and chromatography on silica gel by means of ethyl acetate/petroleum ether 1:1 with addition of 1% glacial acetic acid

출처 및 근거

ORD 기록
ord-5e2b4484594241b88abc525754992300
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265588B1

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