Propofol → 2,6-Diisopropylanisole
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].[C:14](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5]=1[O:13][CH3:14])([CH3:12])[CH3:11]참가 물질
5
실험 절차
A mixture of 2,6-diisopropyl phenol (20 g, 0.11 mol), potassium carbonate (62 g, 0.45 mol), acetone (160 ml) and methyl iodide (28 ml, 0.45 mole) is refluxed for three days. The reaction mixture is filtered through celite, evaporated, dissolved in ether, washed twice with 1M sodium hydroxide, dried over magnesium sulphate and concentrated to afford 15.1 g (0.08 mol, 70%) of 2,6-diisopropyl anisole as a slightly yellow oil.
후처리
- temperatureis refluxed for three days
- filtrationThe reaction mixture is filtered through celite
- customevaporated
- dissolutiondissolved in ether
- washwashed twice with 1M sodium hydroxide
- dry with materialdried over magnesium sulphate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-1f6add6f653b4925b9969c9eb58db831
- 출처 데이터셋
- uspto-grants-2001_07
- 특허 번호
- US06266622B1
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