Methanol → 5-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether

HRID 1386997

반응식

HRID 1386997 반응식
[S:1]1[C:5](B(O)O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[N:13]1([CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24](Br)=[CH:23][N:22]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1.CO>C(Cl)(Cl)Cl>[N:13]1([CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:5]3[S:1][C:2]4[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=4[CH:4]=3)=[CH:23][N:22]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

참가 물질

5

반응물 3

HCID 887MethanolHCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 105881665-Bromo-2-(2-(pyrrolidin-1-yl)ethoxy)pyridine

생성물 1

HCID 211829075-(Benzo[b]thiophen-2-yl)pyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether수율 68%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

By essentially following the procedure detailed in Example 1, Part B, the title compound was prepared from benzo[b]thiophene-2-boronic acid and 5-bromopyrid-2-yl 2-(1-pyrrolidinyl)ethyl ether (Part A) in 68% yield as an oil following flash chromatography (SiO2; gradient of 0-4% MeOH in CHCl3).

출처 및 근거

ORD 기록
ord-2e3a2f64e70b454b8abeeccb29a3e1e6
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06265575B1

연결된 노트

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