Monoethyl malonate → HCID 54441812, 화합물

HRID 1387471노트

반응식

HRID 1387471 반응식
[O:1]1[C:5]2=[N:6][CH:7]=[C:8]([CH:10]=O)[CH:9]=[C:4]2[CH:3]=[CH:2]1.[C:12]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:13]C(O)=O.C([O-])(=O)C.[NH4+:25]>C(O)C>[CH2:19]([O:18][C:12](=[O:17])[CH2:13][CH:10]([NH2:25])[C:8]1[CH:9]=[C:4]2[CH:3]=[CH:2][O:1][C:5]2=[N:6][CH:7]=1)[CH3:20]

참가 물질

5

반응물 3

HCID 70615Monoethyl malonateHCID 517165Ammonium AcetateHCID 10749327furo[2,3-b]pyridine-5-carbaldehyde

생성물 1

HCID 54441812HCID 54441812, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution containing aldehyde 22-2 (1.5 g, 10 mmol), ethyl hydrogen malonate (1.6 g, 20 mmol), and ammonium acetate (3.8 g, 50 mmol) in anhydrous ethanol (125 mL) was heated at reflux for 8 h. After cooling to room temperature, the solvent was evaporated and the residue partitioned between sat. sodium bicarbonate and EtOAc, the organic layer removed, dried, and concentrated. Chromatography of the residue afforded the amino ester 22-3 as a waxy solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 8 h
  3. customthe solvent was evaporated
  4. customthe residue partitioned between sat. sodium bicarbonate and EtOAc
  5. customthe organic layer removed
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a75ef70b884a448a8cc31d2a617658cd
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268378B1

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