Pyridine → HCID 799182, 화합물

HRID 1387695노트

반응식

HRID 1387695 반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].N1C=CC=CC=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1>C(Cl)(Cl)Cl>[CH3:11][O:10][C:1](=[O:9])[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][S:26]([C:23]1[CH:22]=[CH:21][C:20]([O:19][CH3:18])=[CH:25][CH:24]=1)(=[O:28])=[O:27]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 74014-Methoxybenzenesulfonyl chlorideHCID 8635Methyl Anthranilate

생성물 1

HCID 799182HCID 799182, 화합물수율 88.6%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 2.00 g (0.013 mol) of methyl anthranilate dissolved in 20 mL of chloroform was added 3.2 mL (0.039 mol) of pyridine followed by 2.733 g (0.013 mol) of p-methoxybenzenesulfonyl chloride. The reaction mixture was stirred at room temperature for 5 h and then washed with 3N HCl and water. The organics were then dried over Na2SO4, filtered and concentrated in vacuo. The resulting white solid was washed with ether and dried in vacuo to provide 3.7 g (87%) of the desired sulfonamide. CI Mass Spec: 322 (M+H).

후처리

  1. washwashed with 3N HCl and water
  2. dry with materialThe organics were then dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. washThe resulting white solid was washed with ether
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-416ea893809444bca5e7a77caf10b9e3
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268504B1

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