3-Ethylpyridine → 3-Ethyl-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride

HRID 1387807

반응식

HRID 1387807 반응식
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][C:16]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)=[CH:17][CH:18]=3)[CH:13]=2)=[O:11])=[CH:5][CH:4]=1.[CH2:28]([C:30]1[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=1)[CH3:29]>CN(C=O)C>[Cl-:1].[CH2:28]([C:30]1[CH:31]=[N+:32]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]3[CH2:21][CH2:20][C:19]4[C:14](=[CH:15][C:16]([C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=5)=[CH:17][CH:18]=4)[CH:13]=3)=[O:11])=[CH:5][CH:4]=2)[CH:33]=[CH:34][CH:35]=1)[CH3:29]

참가 물질

4

반응물 2

HCID 108233-EthylpyridineHCID 10809385N-[4-(chloromethyl)phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide

생성물 1

HCID 184725723-Ethyl-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

In DMF (3 ml) was dissolved N-[4-(chloromethyl)-phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (160 mg), and to the mixture was added 3-ethylpyridine (146 μl). The mixture was stirred at 70° C. for 72 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 3-ethyl-1-[4-(7-phenyl-3,4-dihydronaphthalene-2-carboxamido)benzyl]pyridinium chloride (Compound 27) (185 mg) as colorless crystals.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was recrystallized from ethyl acetate-methanol

출처 및 근거

ORD 기록
ord-4cae7f802b1f43ceb0594a0fd2589469
출처 데이터셋
uspto-grants-2001_07
특허 번호
US06268354B1

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