1-Methylhomopiperazine → Emedastine

HRID 1388162

반응식

HRID 1388162 반응식
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][CH3:11])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=1.[CH3:16][N:17]1[CH2:23][CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.C(O)(=O)/C=C/C(O)=O>>[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=[C:2]1[N:20]1[CH2:21][CH2:22][CH2:23][N:17]([CH3:16])[CH2:18][CH2:19]1)[CH3:11]

참가 물질

4

반응물 3

HCID 2283491-MethylhomopiperazineHCID 444972Fumaric AcidHCID 104893562-chloro-1-(2-ethoxyethyl)-1H-benzimidazole

생성물 1

HCID 3219Emedastine

실험 절차

In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (3.00 g), N-methylhomopiperazine (3.10 g) and fumaric acid (2.63 g), ther are obtained crude crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole.difumarate (3.78 g) as colorless needles, m.p. 141°-143° C.

후처리

  1. customther are obtained crude crystals, which
  2. customare recrystallized from ethyl acetate-ethanol

출처 및 근거

ORD 기록
ord-7062adf2730f4b1ba33bbc33e7b310dd
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04430343

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