Water → 2-(4-Methylphenyl)quinazolin-4(3H)-one

HRID 1388236노트

반응식

HRID 1388236 반응식
[C:1]([C:4]1[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=1[NH:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)=O)(=[O:3])[NH2:2].[OH-].[Na+].O>C(O)(=O)C>[CH3:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]2[NH:2][C:1](=[O:3])[C:4]3[C:5](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:6]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 8196472-[(4-methylbenzoyl)amino]benzamide

생성물 1

HCID 1354521092-(4-Methylphenyl)quinazolin-4(3H)-one

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2'-carbamoyl-p-toluanilide (66.97 g; 0.263 mol), sodium hydroxide (41.9 g) and water 837 ml) is stirred and heated at reflux for 0.5 hour. The resultant solution is cooled down, made acid with acetic acid. The reaction mixture is filtered, the isolated product is washed and dried to afford 58.16 g off white solid, mp 239°-241° C. Recrystallized from absolute ethanol, the product has a mp of 239°-240.5° C.

후처리

  1. temperatureheated
  2. temperatureat reflux for 0.5 hour
  3. filtrationThe reaction mixture is filtered
  4. washthe isolated product is washed
  5. customdried
  6. customto afford 58.16 g off white solid, mp 239°-241° C
  7. customRecrystallized from absolute ethanol

출처 및 근거

ORD 기록
ord-f041c9964c7241bf930d40ac3ff617ab
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431440

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