Hydrochloric Acid → 4-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one

HRID 1388295

반응식

HRID 1388295 반응식
[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][CH2:12][C:13]3=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:19](OCCC(C)C)=[O:20].Cl>CCOCC>[OH:20][N:19]=[C:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[CH:17][C:9]=2[O:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:13]1=[O:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 136161924-(benzyloxy)-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 714128754-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one수율 86%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To an ice-cooled solution of 1.91 g (0.008 m) of 4-(phenylmethoxy)-1-indanone in 75 ml of anhydrous ether is added dropwise with stirring 1.2 ml (0.088 m) of isoamyl nitrite while hydrogen chloride is simultaneously bubbled in. After stirring at room temperature for twenty minutes, the reaction mixture is partially concentrated and the solid which separates is filtered to yield 1.83 g (86%) of material sufficiently pure to be used in the next step.

후처리

  1. additionis added dropwise
  2. customis simultaneously bubbled in
  3. concentrationthe reaction mixture is partially concentrated
  4. filtrationthe solid which separates is filtered

출처 및 근거

ORD 기록
ord-430e74d3c7b841a39e0c9156e5302765
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431647

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