1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dichlorophenyl)-1,3-thiazole

HRID 1388302노트

반응식

HRID 1388302 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH2:7])=[S:6].[Cl:12][CH2:13][C:14]([CH2:16]Cl)=O>CC(C)=O>[Cl:12][CH2:13][C:14]1[N:7]=[C:5]([C:4]2[CH:8]=[CH:9][C:10]([Cl:11])=[C:2]([Cl:1])[CH:3]=2)[S:6][CH:16]=1

참가 물질

4

반응물 2

HCID 107931,3-DichloroacetoneHCID 20608953,4-Dichlorothiobenzamide

생성물 1

HCID 131863604-(Chloromethyl)-2-(3,4-dichlorophenyl)-1,3-thiazole

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3,4-dichlorothiobenzamide (8.24 g., 0.04 mol), 1,3-dichloroacetone (5.1 g., 0.04 mol) in acetone (150 ml) was stirred at room temperature overnight. After evaporation of the acetone under reduced pressure, the residue was dissolved in methanol (150 ml) and the solution refluxed 11/2 hours. After cooling and removal of the methanol, the residue was slurried with a small quantity of methanol. The solids which formed after filtration showed m.p. 93°-96° C. (6.05 g.).

후처리

  1. customAfter evaporation of the acetone under reduced pressure
  2. dissolutionthe residue was dissolved in methanol (150 ml)
  3. temperaturethe solution refluxed 11/2 hours
  4. temperatureAfter cooling
  5. customremoval of the methanol
  6. customThe solids which formed
  7. filtrationafter filtration

출처 및 근거

ORD 기록
ord-b4c7d1242fc44590aa78f89654b9bfb5
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431652

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