Acetonitrile → 4-(Trifluoromethoxy)benzoyl azide

HRID 1388366

반응식

HRID 1388366 반응식
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](F)=[O:9])=[CH:6][CH:5]=1.[N-:15]=[N+:16]=[N-:17].[Na+].C1OCCOCCOCCOCCOCCOC1.C(#N)C>C(OCC)C>[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([N:15]=[N+:16]=[N-:17])=[O:9])=[CH:6][CH:5]=1

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 2855718-Crown-6HCID 33557Sodium AzideHCID 67612Benzoyl fluoride, 4-(trifluoromethoxy)-

생성물 1

HCID 132813144-(Trifluoromethoxy)benzoyl azide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 5 grams (24 mmol) of 4-(trifluoromethoxy)benzoyl fluoride, 1.87 grams (29 mmol) of sodium azide, 0.2 grams of 18-Crown-6 ether, and 20 ml. of acetonitrile was stirred at room temperature for two hours under an atmosphere of dry nitrogen. The reaction mixture was diluted with diethyl ether, filtered and concentrated under reduced pressure, with a bath temperature of 40° C., to give the title compound as a turbid oil. IR showed adsorptions at 2280, 2240 and 1695 cm-1.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure, with a bath temperature of 40° C.

출처 및 근거

ORD 기록
ord-f79fc335e7344fa0a0035b33648b6dbd
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431667

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