Sodium Hydroxide → Bicyclo(3.1.1)heptane-3-methanamine, 2,6,6-trimethyl-

HRID 1388578노트

반응식

HRID 1388578 반응식
Cl.[NH2:2][CH2:3][CH:4]1[CH2:9][CH:8]2[CH2:10][CH:6]([C:7]2([CH3:12])[CH3:11])[CH:5]1[CH3:13].[OH-].[Na+]>C(OCC)(=O)C>[NH2:2][CH2:3][CH:4]1[CH2:9][CH:8]2[CH2:10][CH:6]([C:7]2([CH3:12])[CH3:11])[CH:5]1[CH3:13]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 106575Bicyclo[3.1.1]heptane-3-methanamine, 2,6,6-trimethyl-, hydrochloride (1:1)

생성물 1

HCID 106576Bicyclo(3.1.1)heptane-3-methanamine, 2,6,6-trimethyl-

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

(-)-3-Aminomethylpinane HCl, 9.5 g (46.6 mmole), ethyl acetate (186 ml) and 1 N NaOH (93 ml) were stirred vigorously for 10 minutes. The organic layer was separated, washed 1×93 ml H2O, dried (MgSO4) and stripped to yield (-)-3-aminomethylpinane free base as an oil, 7.75 g (99%) [alpha]D25 =-54.85° (c=1 in methanol), which was then dissolved in 20 ml methanol.

후처리

  1. customThe organic layer was separated
  2. washwashed 1×93 ml H2O
  3. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-11e54d39c18b42acb6e5a7437b3ed711
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04431828

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