Ethanol → 3-Amino-5-ethyl-1-phenyl-2-pyrazoline

HRID 1388734노트

반응식

HRID 1388734 반응식
[Na].[C:2]1([NH:8][NH2:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C/[C:11](=[CH:14]\[CH3:15])/[C:12]#[N:13].[CH2:16](O)C>>[NH2:13][C:12]1[CH2:11][CH:14]([CH2:15][CH3:16])[N:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:9]=1

참가 물질

5

반응물 4

HCID 702EthanolHCID 7516PhenylhydrazineHCID 5355732(E)-2-Methyl-2-butenenitrileHCID 5360545Sodium

생성물 1

HCID 130641963-Amino-5-ethyl-1-phenyl-2-pyrazoline

실험 절차

A 0.23 g. amount of sodium metal is dissolved in 75.0 ml. of absolute ethanol, then 10.8 g. of phenylhydrazine is added, followed in 5 minutes by 3.6 g. of α-methylcrotononitrile. The reaction mixture is refluxed for 18 hours, then is evaporated to dryness in vacuo. Water is added to give a gum which solidifies on standing for 16 hours. The solid is collected and dissolved in dichloromethane. The procedure of Example 15 is continued to give 1.6 g. of the desired product as light yellow crystals, m.p. 123°-125° C.

후처리

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. customis evaporated to dryness in vacuo
  3. additionWater is added
  4. customto give a gum which
  5. waiton standing for 16 hours
  6. customThe solid is collected
  7. dissolutiondissolved in dichloromethane
  8. customto give 1.6 g

출처 및 근거

ORD 기록
ord-5b4f1379201d4904beff940485c56d67
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04432991

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