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Water → N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

HRID 1388739
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반응식

HRID 1388739 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH:10]([OH:13])[CH2:11][NH2:12].[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23]OS(C2C=CC(C)=CC=2)(=O)=O)=[CH:17][CH:16]=1.C(N(CC)CC)C.O>CS(C)=O>[CH3:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][NH:12][CH2:11][CH:10]([C:2]2[O:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[CH:3]=2)[OH:13])=[CH:17][CH:16]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 128143572-Amino-1-(1-benzofuran-2-yl)ethan-1-olHCID 539033013-(4-Methylphenyl)propyl 4-methylbenzene-1-sulfonate

생성물 1

HCID 12816509N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

시약·촉매·용매 1

HCID 679
Dimethyl Sulfoxide
용매

실험 절차

A mixture of 2-(2-benzofuranyl)-2-hydroxyethanamine (1.75 g), 3-(4-methylphenyl)-1-(4-methylphenylsulphonyloxy) propane (3.0 g) and triethylamine (1.5 g) was stirred in dimethylsulphoxide for 2 days at ambient temperature. The mixture was poured into water, extracted with ether and the ether layers dried. Removal of the solvent gave an oil which was crystallised and recrystallised from ether to give N-[3-(4-methylphenyl)propyl]-2-(2-benzofuranyl)-2-hydroxyethanamine m.p. 118°-119°.

후처리

  1. extractionextracted with ether
  2. dry with materialthe ether layers dried
  3. customRemoval of the solvent
  4. customgave an oil which
  5. customwas crystallised
  6. customrecrystallised from ether

출처 및 근거

ORD 기록
ord-d2a087c8d85f4801a77085a20c21022e
출처 데이터셋
uspto-grants-1984_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04432993

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