HCID 12553985, 화합물 → 4-Methoxypyrimidin-5-amine

HRID 1388894노트

반응식

HRID 1388894 반응식
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[CH:5][N:4]=1>CO.[Ni]>[NH2:9][C:8]1[C:3]([O:2][CH3:1])=[N:4][CH:5]=[N:6][CH:7]=1

참가 물질

4

반응물 1

HCID 12553985HCID 12553985, 화합물

생성물 1

HCID 132774654-Methoxypyrimidin-5-amine수율 99.2%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

10 g 4-methoxy-5-nitropyrimidine in 500 ml methanol are hydrated for 2.5 hours at 2 bar in the presence of 4.5 g Raney nickel. After filtration, the solution is concentrated. 8.0 g 5-amino-4-methoxypyrimidine having a melting point of 71° to 74° C. are obtained.

후처리

  1. filtrationAfter filtration
  2. concentrationthe solution is concentrated

출처 및 근거

ORD 기록
ord-58999e9308004d959a9a6d7a0a7620e1
출처 데이터셋
uspto-grants-1984_02
특허 번호
US04434167

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