Methyl iodide → Methyl 1-methyl-4-(methylsulfanyl)-1H-pyrrole-2-carboxylate
반응식
[C:1]([S:3][C:4]1[CH:5]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[N:7]([CH3:9])[CH:8]=1)#N.CI.C[O-].[Na+]>CO>[CH3:13][O:12][C:10]([C:6]1[N:7]([CH3:9])[CH:8]=[C:4]([S:3][CH3:1])[CH:5]=1)=[O:11]참가 물질
5
실험 절차
4-Cyanothio-2-methoxycarbonyl-1-methylpyrrole (2.8 g, 14.3 mmol) is dissolved in 50 ml of methanol under nitrogen. Methyliodide (1.25 ml, 20 mmol) is added followed by 1.08 g (20 mmole) of sodium methoxide. After stirring for about 30 minutes at room temperature, the reaction mixture is concentrated to a paste and then diluted with 100 ml of ethylether. The resulting precipitate is filtered off and the filtrate concentrated to give an oil which is distilled at 100° to 104° at 0.25 mm-Hg to afford 2.2 g (86%) of 2-methoxycarbonyl-4-methylthio-1-methylpyrrole.
후처리
- concentrationthe reaction mixture is concentrated to a paste
- additiondiluted with 100 ml of ethylether
- filtrationThe resulting precipitate is filtered off
- concentrationthe filtrate concentrated
- customto give an oil which
- distillationis distilled at 100° to 104° at 0.25 mm-Hg
출처 및 근거
- ORD 기록
- ord-f1eb8c74659848ad9c68267343a919f7
- 출처 데이터셋
- uspto-grants-1984_02
- 특허 번호
- US04434175
반응 노트
불러오는 중…