Sodium Hydroxide → 3-[3-(Diethylamino)phenyl]propanamide

HRID 1389038노트

반응식

HRID 1389038 반응식
[CH2:1]([N:3]([CH2:14][CH3:15])[C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:8][C:9]#[N:10])[CH3:2].[OH-:16].[Na+]>O>[CH2:14]([N:3]([CH2:1][CH3:2])[C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[CH2:7][CH2:8][C:9]([NH2:10])=[O:16])[CH3:15]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 202979473-[3-(Diethylamino)phenyl]propanenitrile

생성물 1

HCID 202979563-[3-(Diethylamino)phenyl]propanamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 40 parts of 3-diethylamino-hydrocinnamonitrile, 34 parts by volume of 66° Be sulphuric acid and 6 parts of water was heated at 100°-105° C. for an hour. The reaction mixture was then left to cool to about 60° C., then poured on 500 parts of ice. It was neutralized by addition of about 160 parts by volume of a 35° Be solution of sodium hydroxide, while assuring that the temperature of the mixture did not exceed 20° C. After filtering and washing with water, 3-diethylamino-hydrocinnamamide was obtained of the formula: ##STR15## which melted at 59° C.

후처리

  1. temperaturewas heated at 100°-105° C. for an hour
  2. waitThe reaction mixture was then left
  3. additionpoured on 500 parts of ice
  4. customdid not exceed 20° C
  5. filtrationAfter filtering
  6. washwashing with water

출처 및 근거

ORD 기록
ord-43ad45ae9e454cbf9d95b7e1ceffdbd2
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243606

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