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Benzoyl chloride → {4-[2-(6-Methoxynaphthalen-2-yl)propyl]piperazin-1-yl}(phenyl)methanone

HRID 1389050
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HRID 1389050 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:10]1([CH2:16][CH:17]([C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH3:30])[CH:25]=3)[CH:20]=2)[CH3:18])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(N1CCOCC1)C>C(Cl)Cl.CCOCC>[C:1]([N:13]1[CH2:12][CH2:11][N:10]([CH2:16][CH:17]([C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH3:30])[CH:25]=3)[CH:20]=2)[CH3:18])[CH2:15][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 7412Benzoyl chlorideHCID 7525EthylmorpholineHCID 3055305HCID 3055305, 화합물

생성물 1

HCID 3055311{4-[2-(6-Methoxynaphthalen-2-yl)propyl]piperazin-1-yl}(phenyl)methanone

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

Benzoyl chloride (0.58 ml, 5 mmols) is added, at 0° C., to a solution of 2-(2-piperazino-1-methylethyl)-6-methoxynaphthalene (1.42 g, 5 mmols) and N-ethylmorpholine (0.65 ml, 5 mmols) in 15 ml of methylene chloride. The mixture is allowed to return to ambient temperature and stirred for 3 hours. The reaction medium is washed with water and dried over sodium sulphate. Concentration of the mixture yields an oily residue which dissolves in ether and crystallises. The compound is recrystallised from ethyl acetate (15 ml).

후처리

  1. customto return to ambient temperature
  2. washThe reaction medium is washed with water
  3. dry with materialdried over sodium sulphate
  4. customConcentration of the mixture yields an oily residue which
  5. customcrystallises
  6. customThe compound is recrystallised from ethyl acetate (15 ml)

출처 및 근거

ORD 기록
ord-3465046ca378426fa6c710e55f2cf957
출처 데이터셋
uspto-grants-1981_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04243665

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