Bifonazole → HCID 178521215, 화합물

HRID 1389058

반응식

HRID 1389058 반응식
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH:7]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.[Br:25][CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:28]>C(#N)C>[Br-:25].[C:1]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:2]=[CH:3][C:4]([CH:7]([N+:14]2[CH:18]=[CH:17][N:16]([CH2:26][C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:28])[CH:15]=2)[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 2378BifonazoleHCID 6259Phenacyl bromide

생성물 1

HCID 178521215HCID 178521215, 화합물수율 82.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

15.1 g (0.05 mol) of 1-[α-(4-biphenylyl)-benzyl]-imidazole and 10 g (0.05 mol) of ω-bromoacetophenone are suspended in 500 ml of acetonitrile. After stirring for 15 hours at room temperature, the resulting clear solution is concentrated to about 50 ml. The crystals which hereupon separate out are filtered off and dried. 21 g (82.5% of theory) of 1-[α-(4-biphenylyl)-benzyl]-3-phenacylimidazolium bromide of melting point 210° C. (with decomposition) are obtained.

후처리

  1. concentrationthe resulting clear solution is concentrated to about 50 ml
  2. customThe crystals which hereupon separate out
  3. filtrationare filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-49fe7d9561af495989e10a8de316869c
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243670

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