Diethyl Ether → 2,2-Dimethylhexan-1-amine

HRID 1389175

반응식

HRID 1389175 반응식
[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[C:3]#[N:4].CCOCC.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH3:1][C:2]([CH3:9])([CH2:5][CH2:6][CH2:7][CH3:8])[CH2:3][NH2:4]

참가 물질

6

반응물 4

HCID 3283Diethyl Ether2회HCID 14798Sodium HydroxideHCID 35735622,2-DimethylhexanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 543253312,2-Dimethylhexan-1-amine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A solution of 2,2-dimethylcapronitrile (10.0 g., 0.078 mole) in 100 ml. of ether is added slowly to a suspension of lithium aluminum hydride (6.0 g., 0.158 mole) in 200 ml. of ether while maintaining the reaction at 0°-5°. After stirring the reaction mixture for an additional 2 hr. at 0.5°, the mixture is hydrolyzed by sequentially adding 6.0 ml. of water, 6.0 ml. of 15% sodium hydroxide solution, and finally 18 ml. of water. The hydrolyzed mixture is stirred for an additional hour, filtered and the ether phase concentrated under reduced pressure. Distillation of residual material provides 2,2-dimethylhex-1-ylamine.

후처리

  1. customthe reaction at 0°-5°
  2. customat 0.5°
  3. additionby sequentially adding 6.0 ml
  4. stirringThe hydrolyzed mixture is stirred for an additional hour
  5. filtrationfiltered
  6. concentrationthe ether phase concentrated under reduced pressure
  7. distillationDistillation of residual material

출처 및 근거

ORD 기록
ord-46a53f11be494f1fb813261c290bc872
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243681

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