Hydrochloric Acid → 4-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)

HRID 1389236노트

반응식

HRID 1389236 반응식
[O:1]([CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:15]>[Pt]=O.CO>[ClH:15].[O:1]([CH2:8][CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 12472531HCID 12472531, 화합물

생성물 1

HCID 441449484-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)수율 53%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매

실험 절차

A mixture of 18.5 g (0.1 mole) of 4-phenoxymethylpyridine, 250 ml of methanol, 250 ml of 3 N methanolic hydrogen chloride solution and 2 g of platinum oxide is shaken at ambient temperature under a hydrogen pressure of 1 atmosphere absolute. After the take up of the calculated amount of hydrogen, the catalyst is filtered off, the filtrate is evaporated in a vacuum and the residue is recrystallized from ethanol. There are obtained 12.0 g of 4-phenoxymethylpiperidine hydrochloride (53% of theory); m.p. 218°-219° C. The free base is obtained by treating the hydrochloride with an aqueous solution of sodium hydroxide.

후처리

  1. filtrationAfter the take up of the calculated amount of hydrogen, the catalyst is filtered off
  2. customthe filtrate is evaporated in a vacuum
  3. customthe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-f4fc3fe9d3f941be8b38728abf96677f
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243807

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