Sodium borohydride → N-[[3-Methoxy-2-[3-(4-morpholinyl)propoxy]phenyl]methyl]benzeneethanamine

HRID 1389258노트

반응식

HRID 1389258 반응식
[CH3:1][O:2][C:3]1[C:4]([O:19][CH2:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[C:5]([CH:9]=[N:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:7][CH:8]=1.[BH4-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:4]([O:19][CH2:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)=[C:5]([CH2:9][NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 20298672N-[[3-Methoxy-2-[3-(4-morpholinyl)propoxy]phenyl]methylene]benzeneethanamine

생성물 1

HCID 20298679N-[[3-Methoxy-2-[3-(4-morpholinyl)propoxy]phenyl]methyl]benzeneethanamine수율 80.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-[[3-Methoxy-2-[3-(4-morpholinyl)propoxy]phenyl]methylene]benzeneethanamine (49.7 g) is reduced with 14.8 g of sodium borohydride in 225 ml of methanol following the procedure described in Example 1C, yielding 40.2 g of the title compound, boiling point 0.2-0.3 mm of Hg.

출처 및 근거

ORD 기록
ord-e06592ba881c46bfbda1ba0370d0291d
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04243804

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