2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine

반응식

[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[Na].Br[CH:12]([CH:16]([CH3:18])[CH3:17])[C:13]([OH:15])=[O:14]>>[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C@H:12]([C:13]([OH:15])=[O:14])[CH:16]([CH3:18])[CH3:17]

참가 물질

반응물 3

HCID 112682-Bromoisovaleric acid

HCID 938984-Chloro-2-fluoroaniline

HCID 5360545Sodium

생성물 1

HCID 54022058N-(2-fluoro-4-chlorophenyl)valine

실험 절차

Following the procedure of Example 6, 2-fluoro-4-chloroaniline is reacted with m-phenoxy-α-cyanobenzyl α-bromoisovalerate to give the m-phenoxy-α-cyanobenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 452 (M+). Alternatively 2-fluoro-4-chloroaniline is reacted with the sodium salt of α-bromo-isovaleric acid to give N-(2-fluoro-4-chlorophenyl)valine, which is then esterified using m-phenoxy-α-cyanobenzyl bromide or mesylate.

출처 및 근거

ORD 기록: ord-1063e3e5c62b4f5695ca3f66f4d6246c
출처 데이터셋: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04243819

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