Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 8-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Hexachlorodisilane | HCID 83497 | — |
| 반응물 | 8-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine 5-oxide | HCID 13046988 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 8-Chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]benzodiazepine | HCID 13046989 | — |
반응 단계
A mixture of 0.2 g of 8-chloro-6-(2-fluorophenyl)-1-methyl-3-morpholino-4H-imidazo[1,5-a][1,4]-benzodiazepine 5-oxide, 0.2 ml of hexachlorodisilane and 10 ml of methylene chloride was allowed to sit for two days. It was then diluted with toluene and washed with 1 N sodium hydroxide solution. The organic phase was dried and evaporated. Crystallization of the residue from ether/hexane gave end product with mp 172°-174° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04244867 |
| 출처 데이터셋 | uspto-grants-1981_01 |
| ORD ID | ord-5cf16a1add3946ab9d84a4e6b2ca78d0 |
| 출처 메모 | uspto-grants-1981_01 |