Ethyl Thioglycolate → 5-(Carbethoxymethylthio)-1-(2-furyl)-1-pentanol

HRID 1389630노트

반응식

HRID 1389630 반응식
[SH:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl[CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([C:15]1[O:16][CH:17]=[CH:18][CH:19]=1)[OH:14].[O-]CC.[Na+]>C(O)C>[C:3]([CH2:2][S:1][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]([C:15]1[O:16][CH:17]=[CH:18][CH:19]=1)[OH:14])([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

5

반응물 3

HCID 12185Ethyl ThioglycolateHCID 2723922Sodium ethoxide2회HCID 202925795-Chloro-1-(2-furyl)-1-pentanol

생성물 1

HCID 202925745-(Carbethoxymethylthio)-1-(2-furyl)-1-pentanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred, refluxing mixture of 76 g of ethyl mercaptoacetate, 79.5 g of 5-chloro-1-(2-furyl)-1-pentanol (Example), and 10 ml of 1.5 M sodium ethoxide in ethanol is added an additionan 300 ml of 1.5 M sodium ethoxide during 15 minutes. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again concentrated to give an oil, pmr spectrum (CDCl3): δ3.24 (singlet, --S--CH2CO2C2H5) and 4.70 (triplet, CH2CHOH).

후처리

  1. temperatureTo a stirred, refluxing
  2. temperatureat reflux for 3 hours
  3. temperaturecooled
  4. concentrationconcentrated
  5. customto remove most of the ethanol
  6. customThe residue is partitioned with ether and water
  7. washThe ether phase is washed with brine
  8. dry with materialdried over potassium carbonate
  9. concentrationThe solution is concentrated
  10. additiondiluted with xylene
  11. concentrationagain concentrated
  12. customto give an oil, pmr spectrum (CDCl3)

출처 및 근거

ORD 기록
ord-e291fa8fd5f74f74babd6105a3df202a
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04245121

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