Potassium Carbonate → N-Formyl-4-bromomethylpiperidine

HRID 1389769

반응식

HRID 1389769 반응식
Br.[Br:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[C:10](=O)([O-])[O-:11].[K+].[K+]>O.C(OC)=O>[CH:10]([N:7]1[CH2:8][CH2:9][CH:4]([CH2:3][Br:2])[CH2:5][CH2:6]1)=[O:11]

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 135032174-(Bromomethyl)piperidine hydrobromide

생성물 1

HCID 19812293N-Formyl-4-bromomethylpiperidine

시약·촉매·용매 2

HCID 962Water용매HCID 7865Methyl formate용매

실험 절차

To a solution of 4-bromomethylpiperidin hydrobromide (12.8 g, 0.05 mole) in water (5 ml), methyl formate (25 ml) and potassium carbonate (10 g) were added and the mixture stirred for 20 hours. The solvent was decanted, and the residue was extracted with two 25 ml portions of ether. The combined organic phases were washed with water, dried and evaporated to give (A) as a colourless oil. The IR spectrum (chloroform) showed a strong band at 1650 cm-1.

후처리

  1. customThe solvent was decanted
  2. extractionthe residue was extracted with two 25 ml portions of ether
  3. washThe combined organic phases were washed with water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-54a83d9fc37c4287bd1bcfc5f8fc4ffa
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04246262

연결된 노트

불러오는 중…