Hydrochloric Acid → 6-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

HRID 1389862노트

반응식

HRID 1389862 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:19])[CH:15]=3)[CH:10]=2)=[O:8])[CH2:3][CH2:2]1.Cl>CCOCC>[ClH:19].[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:19])[CH:15]=3)[CH:10]=2)=[O:8])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 543200266-Chloro-2-naphthyl 4-piperidyl ketone

생성물 1

HCID 705701616-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

The 6-chloro-2-naphthyl 4-piperidyl ketone prepared in Example 3 is reacted with an excess of HCl dissolved in ether and recrystallized from absolute ethanol to yield 6-chloro-2-naphthyl 4-piperidyl ketone hydrochloride. M.P. 259°-64°.

후처리

  1. customrecrystallized from absolute ethanol

출처 및 근거

ORD 기록
ord-cbe671ccea0b4bed82e8d801e59c6f55
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04246268

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