Hydrogen Bromide → HCID 23455899, 화합물

HRID 1389986노트

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HRID 1389986 반응식
C(OC([C:6]1[O:7][C:8]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25]CC)=[O:24])=[CH:18][CH:17]=3)=[CH:12][C:9]=2[C:10]=1[CH3:11])=O)C.Br>C(O)(=O)C>[CH3:11][C:10]1[C:9]2[CH:12]=[C:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][CH:17]=3)[CH:14]=[CH:15][C:8]=2[O:7][CH:6]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 12902869HCID 12902869, 화합물

생성물 1

HCID 23455899HCID 23455899, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 17 g. of the product of step A in 100 ml. of acetic acid with 35 ml. of 48 percent hydrobromic acid is heated at reflux for three hours, then poured into ice water. This mixture is extracted into dichloromethane, and the extracts are dried to provide 4-(3-methylbenzofuran-5-yl)phenylacetic acid. This intermediate is esterified by heating with a trace of sulfuric acid in ethanol. The product is purified by chromatography on silica gel, eluting with 20 percent dichloromethane in carbon tetrachloride to provide ethyl 4-(3-methylbenzofuran-5-yl)phenylacetate.

후처리

  1. temperatureat reflux for three hours
  2. extractionThis mixture is extracted into dichloromethane
  3. customthe extracts are dried

출처 및 근거

ORD 기록
ord-6ff3910ed89147418a01288f1b24736d
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247469

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