Acetic Anhydride → N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

HRID 1390006노트

반응식

HRID 1390006 반응식
[CH3:1][C:2]1[N:3]([NH:8][C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([N:8]([N:3]1[C:4]([CH3:7])=[CH:5][CH:6]=[C:2]1[CH3:1])[C:9]1[N:10]=[N:11][C:12]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[CH:13][CH:14]=1)(=[O:23])[CH3:22]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 711434-(6-((2,5-Dimethylpyrrol-1-yl)amino)-3-pyridazinyl)morpholine

생성물 1

HCID 23276131N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
110 °C

실험 절차

A mixture of 6 g (22 m mol) of N-(2,5-dimethyl-1H-pyrrol-yl)-6-morpholino-3-pyridazineamine, 30 ml of acetic anhydride, and 6 ml of pyridine is heated for one hour at 110° C. The reaction mixture is evaporated to dryness under vacuum and the oily residue is dissolved in 150 ml of ethyl acetate. The organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate and then with 50 ml of water.

후처리

  1. customThe reaction mixture is evaporated to dryness under vacuum
  2. dissolutionthe oily residue is dissolved in 150 ml of ethyl acetate
  3. washThe organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate

출처 및 근거

ORD 기록
ord-77a61adbb99741d4b65194677054727a
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247551

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