Acetic Acid → 2-Benzyl-5-(bromomethyl)-3-(methylsulfanyl)benzene-1-sulfonamide

HRID 1390053노트

반응식

HRID 1390053 반응식
[CH2:1]([C:8]1[C:15]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:14][C:11]([CH2:12]O)=[CH:10][C:9]=1[S:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(=O)C.[BrH:26]>O>[CH2:1]([C:8]1[C:15]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:14][C:11]([CH2:12][Br:26])=[CH:10][C:9]=1[S:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 20360840HCID 20360840, 화합물

생성물 1

HCID 202945462-Benzyl-5-(bromomethyl)-3-(methylsulfanyl)benzene-1-sulfonamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-Benzyl-3-methylthio-5-sulfamylbenzyl alcohol (10 g; prepared as described in Example 1) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (50 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with water (100 ml) and cooled to precipitate crude 4-benzyl-3-methylthio-5-sulfamylbenzyl bromide. After recrystallization from methanol it is obtained with a melting point of 149°-150° C.

후처리

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate crude 4-benzyl-3-methylthio-5-sulfamylbenzyl bromide
  4. customAfter recrystallization from methanol it
  5. customis obtained with a melting point of 149°-150° C.

출처 및 근거

ORD 기록
ord-cb6f2699e75d4da4bf08e2393a3b34ac
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247550

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