Acetic Acid → 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

HRID 1390054노트

반응식

HRID 1390054 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5]O.C(O)(=O)C.[BrH:25]>C(OCC)C>[BrH:25].[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5][Br:25]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 536869293-Amino-2-benzyl-5-(hydroxymethyl)benzene-1-sulfonamide

생성물 1

HCID 202945373-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3-Amino-4-benzyl-5-sulfamylbenzyl alcohol (12.5 g; prepared as described in Example 4) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (60 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with diethyl ether (150 ml) and cooled to precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

후처리

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

출처 및 근거

ORD 기록
ord-be722eee992243dd98d238ae479cf8cb
출처 데이터셋
uspto-grants-1981_01
특허 번호
US04247550

반응 노트

불러오는 중…